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IMMORTAL LIFE OF HENRIETTA LACKS Ilert Itcr Iltwe yella .t.\(7 VSey 141.4I101 nettmia4 .eel a wultialilRar-4.12., Alen kr+ bmui EBECCA SKLOOT THE IMMORTAL LIFE OF HENRIETTA LACKS By Rebecca Skloot CROWN 384 PAGES, $26 LISTEN to Rebecca Skloot talk about her research at 3601 S. Congress off E. Alpine Penn Field under the water tower check our site for monthly calendar Ruin Haan it International Headquarters Come Visit us for LUNCH! In addition to our organic coffee, pizzas, empanadas, pastries and pies, we now prepare made to order sandwiches, salads, and even black bean gazpacho. Supporting The Texas Observer with every referral and transaction. You Know Me Get real estate help from someone you know. Call me today! Larry Hurlbert, Realtor 512.431.5370 [email protected] The Kinney Company, Real Estate Services, Austin, TX BOOK REVIEW Culture Divide by Todd Moye ENRIETTA LACKS WAS MOSTLY AN unremarkable person in life. Like millions of African Americans of her generation, she took part in the Great Migration in the 1940s, leaving the rural Jim Crow South for better economic opportunities and greater social freedom in the urban North. Had it not been for a carcinoma that doctors discovered when she complained of abdominal pain and mysterious bleeding, Lacks would have remained anonymous to all but her working-class family. The cancer cells that began covering her cervix at age 30 spread quickly, necessitating painful radiation treatments. Lacks succumbed to the cancer far too young, leaving five children without a mother. A Christian woman, she believed her faith would give her eternal life. In reality, the source of her immortality was man-made. In 1951, doctor at Baltimore’s Johns Hopkins Hospital removed cancerous tissue from Lacks and gave it to research scientists who attempted to grow the cells in a laboratory culture. They had been failing to grow human cells in test tubes for three decades, and they were amazed at how vigorously these cellscoded HeLa, after the first two letters of the donor’s first and last namesgrew. There are hints, but no convincing scientific explanation, as to why these particular cells grow as well as they do in culture. They’re a collective wondera miracle, if you prefer. The team began sharing samples with colleagues at other institutions who needed live human cells for their own research. No one asked permission from Lacks or her family, and the family did not learn of their mother’s unwitting donation to science for another quarter-century. The size and scope of Lacks’ contribution are inestimable. HeLa cells have been used in the basic research that led to the polio vaccine, the human papillomavirus and nearly every other biomedical advance of the past half-century. When a cure for cancer is discovered, it will likely stand on research made possible by Lacks. The HeLa cells allow researchers the world over to “work with the same cells, growing in the same media, using the same equipment,” thereby replicating studies more efficiently and speeding the pace of discoveries. The stock of HeLa cells used today in research across the globe would be measured in tons, and it would be impossible to guess how many billions of dollars the cell line has earned for biomedical companies. As Henrietta’s cousin Cootie puts it in Skloot’s moving account, “It sound strange, but her cells done lived longer than her memory” Lacks’ family has had a hard time reconciling with this reality, to put it mildly, and this wrestling match electrifies Skloot’s book. Lawrence Lacks rails, “It’s not fair! … If our mother is so important to science, why can’t we get health insurance?” The family believes Lacks was violated and that her survivors have been wronged by the medical community. It’s not entirely clear this is the case. Skloot documents the fact that the doctors of Johns Hopkins provided much better than average medical care to Baltimore’s charity cases, but their failure to communicate with the Lacks family gave conspiracy theories exactly the medium they needed to grow and mutate. Medical ethics of the time did not require the informed consent of human research subjects, and Lacks was not even a research subject per se; she was a tissue donor. Skloot leaves little doubt that, in a strictly legal sense, the family has no claim to the profits HeLa has generated. Skloot doesn’t shy away from these judgments, but neither does she deny her deep and complicated affection for the family. To her credit, she takes the Lackses and their efforts to make sense of their history seriously. Skloot writes about scientific research for lay readers as well as anyone, and her explorations into the evolving field of medical ethics arrive at a welcome time. However, this masterpiece of creative nonfiction is less about laboratory discoveries than larger issues of race, class, religious belief and how we relate to one another. At times maddening, at times uplifting, it is always thought-provoking and fulfilling. Todd Moye teaches U.S. history and directs the Oral History Program at the University of North Texas in Denton.